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Antihypertensive treatment may have reduced the rate of dementia in older patients with isolated systolic hypertension

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Question In older patients with isolated systolic hypertension, can antihypertensive treatment prevent dementia?

Design

Randomised, double blind, placebo controlled trial with up to 5 years of follow up (an optional project in the systolic hypertension in Europe [Syst-Eur] trial).

Setting

106 centres in Europe.

Patients

2470 patients who were ≥60 years of age and had a systolic blood pressure (BP) (when seated) of 160–219 mm Hg and a diastolic BP <95 mm Hg. 2418 patients (98%) were analysed (mean age 70 y, 66% women).

Intervention

After stratification by sex, centre, and previous cardiovascular complications, patients were allocated to …

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