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Bupropion alone or with a nicotine patch increased smoking cessation rates

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Question What is the relative effectiveness of bupropion, a nicotine patch, placebo, and bupropion plus a nicotine patch for smoking cessation?


Randomised, double blind, placebo controlled trial with 1 year follow up.


4 centres in the US.


893 people ≥18 years of age (mean age 43 y, 52% women) who weighed ≥100 lb (≥45.4 kg), were motivated to stop smoking, and who smoked ≥15 cigarettes/day. Exclusion criteria included serious physical or psychiatric illness, pregnancy, lactation, and previous nicotine replacement therapy. Follow up was 80%.


Patients were allocated to 9 weeks of either sustained release bupropion, 150 mg/day for days 1 to 3 and 300 mg/day for days 4 to 63 (n=244); nicotine patch, 21 mg/day for weeks 2 to 7, 14 mg/day for week 8, and 7 mg/day for week 9 (n=244); or bupropion plus a nicotine patch (n=245); or placebo (n=160). Patients stopped smoking on day 8 and received counselling for 1 year.

Main outcome measures

Self reported point prevalence rate of abstinence in the previous 7 …

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