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Randomised, double blind, placebo controlled trial with 1 year follow up.
4 centres in the US.
893 people ≥18 years of age (mean age 43 y, 52% women) who weighed ≥100 lb (≥45.4 kg), were motivated to stop smoking, and who smoked ≥15 cigarettes/day. Exclusion criteria included serious physical or psychiatric illness, pregnancy, lactation, and previous nicotine replacement therapy. Follow up was 80%.
Patients were allocated to 9 weeks of either sustained release bupropion, 150 mg/day for days 1 to 3 and 300 mg/day for days 4 to 63 (n=244); nicotine patch, 21 mg/day for weeks 2 to 7, 14 mg/day for week 8, and 7 mg/day for week 9 (n=244); or bupropion plus a nicotine patch (n=245); or placebo (n=160). Patients stopped smoking on day 8 and received counselling for 1 year.
Main outcome measures
Self reported point prevalence rate of abstinence in the previous 7 …
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