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Apolipoprotein E ε4 allele predicted an accelerated rate of cognitive decline in Alzheimer's disease
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Question In patients newly diagnosed with Alzheimer's disease (AD), what effect do different apolipoprotein E (APOE) genotypes have on the rate of cognitive decline?

Design

Inception cohort followed up for 1–6 years (mean 2.47 y).

Setting

Health maintenance organisation in Seattle, Washington, USA.

Patients

201 patients who were diagnosed with AD within the previous year based on National Institute of Neurological and Cognitive Disorders and Stroke-Alzheimer's Disease and Related Disorders Association and DSM-III-R criteria. Patients with other central nervous system conditions or major psychiatric disorders were excluded.

Assessment of prognostic factors

Patients were grouped according to their APOE genotype: ε2/3 (n=14), ε3/3 (n=75), ε3/4 (n=82), and ε4/4 (n=30).

Main outcome measure

Annual rate of cognitive decline assessed by the Dementia Rating Scale (DRS) total scores …

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  • Correction
    BMJ Publishing Group Ltd, Royal College of Psychiatrists and British Psychological Society