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Paroxetine reduced symptoms and avoidance in generalised social phobia

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Question In patients with generalised social phobia (social anxiety disorder), how effective is paroxetine compared with placebo?


Randomised, double blind, placebo controlled trial with 12 weeks follow up.


13 centres in the US and 1 centre in Canada.


187 patients ≥18 years of age (mean age 36 y, 57% women) with a DSM-IV diagnosis of generalised social phobia. Exclusion criteria included concurrent use of psychoactive medication, narcotic analgesics, warfarin sodium, digitalis glycosides, phenytoin, cimetidine or sulfonylurea derivatives; use of any psychotropic agent or β blockers within the previous 14 weeks; use of depot neuroleptics within the previous 12 weeks; clinically predominant Axis I diagnosis within the previous 6 months; substance abuse or substance dependence; and those considered to be serious …

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