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Review: quetiapine leads to fewer withdrawals because of adverse effects in schizophrenia

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Question In patients with schizophrenia, is quetiapine effective and what are the adverse effects?

Data sources

Studies were identified by searching Biological Abstracts, CINAHL, the Cochrane Library, Cochrane Schizophrenia Group's Register, EMBASE/Excerpta Medica, Medline, PsycLIT, SIGLE, and Sociofile; handsearching 6 journals and conference proceedings; and contacting experts in the field.

Study selection

Studies were selected if they were randomised controlled trials evaluating the effectiveness of quetiapine compared with placebo or other neuroleptic drugs in patients (16–65 y of age) with schizophrenia or similar illnesses.

Data extraction

Data were extracted on study design, patient characteristics, treatment type and duration, and main outcome measures.

Main results

7 short term trials met the selection criteria. In each comparison, >30% of each participant …

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