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Question In patients with schizophrenia, is quetiapine effective and what are the adverse effects?
Studies were identified by searching Biological Abstracts, CINAHL, the Cochrane Library, Cochrane Schizophrenia Group's Register, EMBASE/Excerpta Medica, Medline, PsycLIT, SIGLE, and Sociofile; handsearching 6 journals and conference proceedings; and contacting experts in the field.
Studies were selected if they were randomised controlled trials evaluating the effectiveness of quetiapine compared with placebo or other neuroleptic drugs in patients (16–65 y of age) with schizophrenia or similar illnesses.
Data were extracted on study design, patient characteristics, treatment type and duration, and main outcome measures.
7 short term trials met the selection criteria. In each comparison, >30% of each participant …
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