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Cognitive behavioural therapy was effective for adolescent depression after controlling for adverse predictors of outcome

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Question In adolescents with depression, what are the predictors of treatment outcome and of differential treatment response when evaluating the effectiveness of 3 psychosocial therapies?


Randomised controlled trial with follow up to the end of treatment (range 12–16 weeks).


Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA.


107 adolescent outpatients 13–18 years of age with a DSM-III-R diagnosis of major depression and a Beck Depression Inventory (BDI) score ≥13. Exclusion criteria were psychotic, bipolar, or obsessive-compulsive disorder; eating disorder; substance abuse; or ongoing physical or sexual abuse.


Patients were allocated to 1 of 3 manual based, brief (12–16 sessions) psychosocial treatments: cognitive behavioural therapy (CBT), systemic behavioural family therapy (SBFT), or non-directive supportive therapy (NST).

Main outcome measures

Presence of DSM-III-R major …

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