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Inception cohort of patients followed for up to 12 years (mean follow up 8.5 y) (National Institute of Mental Health Collaborative Depression Study).
5 tertiary care centres in the US.
431 patients were enrolled in the study, of whom 122 (28%, mean age 39 y, 52% women)* had a first episode of major depressive disorder without dysthymia according to the Research Diagnostic Criteria derived from the Schedule for Affective Disorders and Schizophrenia; spoke English; were white; had an IQ score ≥70; and had no evidence of organic mental disorder, terminal medical illness, bipolar disorder, schizoaffective disorder, or schizophrenia.
Assessment of prognostic factors
Interviews were …
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