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Pharmacological interventions
Are sertraline, paroxetine and duloxetine the most effective antidepressants for use in depressed adults over 60 years?
  1. Waguih William IsHak1,
  2. Lancer Naghdechi2
  1. 1Cedars Sinai Medical Center and UCLA—Psychiatry, Los Angeles, California, USA;
  2. 2Western University of Health Sciences—College of Osteopathic Medicine of the Pacific, Pomona, California, USA
  1. Correspondence to Dr Waguih William IsHak; Waguih.IsHak{at}

Statistics from

ABSTRACT FROM: Thorlund K, Druyts E, Wu P, et al. Comparative efficacy and safety of selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in older adults: a network meta-analysis. J Am Geriatr Soc 2015;63:1002–9.

What is already known on this topic

Although major depressive disorder (MDD) is less prevalent in older adults compared to in younger individuals, its somatic and psychological effects differ in these age groups.1 As such, it is important to evaluate the efficacy, safety and relative risk (RR) of antidepressants in patients with MDD, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs), as they are widely prescribed.2 The findings of this research are crucial to the field, as it will aid in determining treatment regimens for this population.

Methods of the study

The authors searched Medline, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, Web of Science, and conference proceedings of major psychiatric conferences of the …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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