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ABSTRACT FROM: Thorlund K, Druyts E, Wu P, et al. Comparative efficacy and safety of selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in older adults: a network meta-analysis. J Am Geriatr Soc 2015;63:1002–9.
What is already known on this topic
Although major depressive disorder (MDD) is less prevalent in older adults compared to in younger individuals, its somatic and psychological effects differ in these age groups.1 As such, it is important to evaluate the efficacy, safety and relative risk (RR) of antidepressants in patients with MDD, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs), as they are widely prescribed.2 The findings of this research are crucial to the field, as it will aid in determining treatment regimens for this population.
Methods of the study
The authors searched Medline, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, Web of Science, clinicaltrials.gov and conference proceedings of major psychiatric conferences of the …
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