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ABSTRACT FROM: Brent DA, Brunwasser SM, Hollon SD, et al. Effect of a cognitive-behavioral prevention program on depression 6 years after implementation among at-risk adolescents: a randomized clinical trial. JAMA Psychiatry 2015;72:1110–18.
What is already known on this topic
Adolescent depression has an adverse effect on school, social and family functioning, and increases the risk of suicide and substance misuse in young adulthood.1 Parental depression is an important risk factor for the development of adolescent depression.2 Children of parents with depression have a twofold to threefold increased risk of developing depressive disorders compared with the offspring of healthy parents.3 Preventive interventions targeting offspring of depressed parents have shown promising short-term effects, although the long-term effects are unknown.4
Methods of the study
In a multicentre (4 US sites) randomised controlled trial, 316 adolescent offspring (aged 13–17 years) of parents with a current or prior depressive disorder within the past 3 years were recruited from August …
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