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ABSTRACT FROM: Reefhuis J, Devine O, Friedman JM, et al. Specific SSRI and birth defects: Bayesian analysis to interpret new data in the context of previous reports. BMJ 2015;350:h3190.
What is already known on this topic
Several observational studies have been conducted on the use of selective serotonin reuptake inhibitors (SSRIs) in pregnancy and the risk of congenital malformations, providing conflicting results.1 Conflicting results among studies can be easily explained by methodological shortcomings that are often inherent to the clinical setting.2 For instance, since the outcomes are very rare, aggregate end points (ie, clusters of birth defects that may affect different organs and systems) are usually employed when the sample does not have sufficient power to detect an association. Likewise, aggregate exposures (ie, an entire drug class, such as SSRIs) can be adopted. These methodological decisions imply that all birth …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.