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Lack of improvement at week 2 predicts later antipsychotic non-response in people with acute exacerbations of schizophrenia or schizophrenia-like psychosis
  1. Taro Kishi
  1. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan;

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ABSTRACT FROM: Samara MT, Leucht C, Leeflang MM, et al. Early improvement as a predictor of later response to antipsychotics in schizophrenia: a diagnostic test review. Am J Psychiatry 2015;172:617–29.

What is already known on this topic?

  • Because there is no conclusive evidence on whether early signs of improvement predict later non-response to antipsychotics in patients with schizophrenia spectrum disorders, the treatment guidelines for schizophrenia, such as those from National Institute for Health and Care Excellence,1 remain unclear as to when a treatment should be changed if patients are unresponsive to a recently prescribed antipsychotic.

  • Therefore, Samara and colleagues performed this diagnostic meta-analysis to examine whether a lack of significant improvement at week 2 could predict ultimate treatment failure.

Methods of the study

The diagnostic test meta-analysis using mostly individual patient data was conducted to assess whether lack of improvement at week 2 predicts later non-response …

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  • Competing interests TK has received speaker's honoraria from AbbVie, Astellas, Daiichi Sankyo, Dainippon Sumitomo, Eisai, Eli Lilly, GlaxoSmithKline, Janssen, Yoshitomi, Otsuka, Meiji, Shionogi, Tanabe-Mitsubishi, Tsumura, Novartis and Pfizer, and grants from Astellas within the past 2 years.

  • Provenance and peer review Commissioned; internally peer reviewed.

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