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ABSTRACT FROM: Dougherty DD, Rezai AR, Carpenter LL, et al. A randomized sham-controlled trial of deep brain stimulation of the ventral capsule/ventral striatum for chronic treatment-resistant depression. Biol Psychiatry 2014. Published Online First.
What is already known on this topic
The evidence from multiple open-label trials documents the efficacy and safety of Deep brain stimulation (DBS) in the treatment of refractory depression (TRD).1 Nonetheless, randomised sham-control trials are required to determine whether the effect is directly related to active electrical stimulation or to the non-stimulation effects.
Methods of the study
This was a multicentre randomised sham-controlled trial of DBS at the ventral capsule/ventral striatum (VC/VS). Thirty patients with chronic, non-psychotic, unipolar TRD were recruited from five centres that used comparable surgical targeting, in the USA. Patients received active or sham stimulation (1:1) in a double-blinded fashion for 16 weeks, followed by a 24-month open-label phase of active stimulation. During the blinded phase, high-frequency bilateral stimulation with two different fixed pulse …
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