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Psychotic disorders cause the greatest mortality disparity among mental disorders, though more deaths are attributable overall to mood and anxiety disorders
  1. Daniel W Bradford,
  2. Natasha Cunningham
  1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
  1. Correspondence to Dr Daniel W Bradford; Daniel.bradford{at}

Statistics from

ABSTRACT FROM: Walker ER, McGee RE, Druss BG. Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry 2015;72:334–41.

What is already known on this topic

It is of great concern to clinicians, patients and policymakers internationally that individuals with mental disorders experiencing worse overall health and earlier death than those without these disorders. The difference in populations studied and methods used has produced substantial variability in estimates of mortality ratios and years of life lost in those with mental disorders. For example, one study1 in the USA estimates years of life lost at about 30 years in people with mental disorders compared to those without these problems, while other studies2 have indicated smaller differences.

Methods of the study

This systematic review and meta-analysis examined mortality risk among people with psychiatric conditions and differences in risk by cause of death, diagnosis and study characteristics. Data sources included EMBASE, MEDLINE, PsychINFO …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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