Article Text

Download PDFPDF
Impact of additive alcohol and substance use disorders on the mortality of people with schizophrenia and mood disorders
  1. Chin-Kuo Chang
  1. Correspondence to King's College London, London, UK; chin-kuo.chang{at}

Statistics from

ABSTRACT FROM: Hjorthøj C, Østergaard ML, Benros ME, et al. Association between alcohol and substance use disorders and all-cause and cause-specific mortality in schizophrenia, bipolar disorder, and unipolar depression: a nationwide, prospective, register-based study. Lancet Psychiatry 2015;2:801–8.

What is already known on this topic

Excess mortality has been well described among people with severe mental illness (SMI) or substance use disorders (SUDs) in various settings.1 However, research about how SUDs impact mortality for people with SMI is scarce.2 To further address the issues on the potential contribution of SUDs on elevated mortality in people with SMI (defined as schizophrenia, bipolar disorder and unipolar depression), studies evaluating mortality in SMI cohorts in relation to SUDs are warranted.

Methods of the study

This cohort study was based on the nationwide Danish register systems with identified schizophrenia, bipolar disorder or unipolar depression patients and their demographics, diagnoses of SUDs, date and primary cause of death. A total of 41 470 patients with schizophrenia, 11 739 with bipolar …

View Full Text


  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.