Statistics from Altmetric.com
ABSTRACT FROM: Andersson E, Hedman E, Enander J, et al. d-Cycloserine vs placebo as adjunct to cognitive behavioral therapy for obsessive-compulsive disorder and interaction with antidepressants: a randomized clinical trial. JAMA Psychiatry 2015;72:659–67.
What is already known on this topic
d-Cycloserine (DCS) is a partial agonist at the N-methyl-d-aspartate receptor, which facilitates extinction learning in animal models and augments exposure therapy in humans with anxiety disorders and obsessive-compulsive disorder (OCD).1 In OCD, there have been other small randomised, placebo-controlled trials, in children and adults, examining DCS augmentation of exposure therapy, with inconsistent findings as to whether DCS is superior to placebo at post-treatment or follow-up.2–4 This study, which examined the efficacy of DCS augmentation of a validated internet-based cognitive–behavioural therapy (ICBT) for OCD, is the first large-scale trial on DCS augmentation of CBT for OCD, and contributes to a growing body of literature on the moderators of DCS efficacy, suggesting that DCS is not universally effective.
Methods of the study
Andersson and …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.