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SSRIs have a smaller benefit in paediatric when compared to adult major depressive disorder
  1. Leo Sher
  1. Correspondence to James J. Peters Veterans’ Administration Medical Center and Icahn School of Medicine at Mount Sinai, New York, New York, USA; Leo.Sher{at}

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ABSTRACT FROM: Varigonda AL, Jakubovski E, Taylor MJ, et al. Systematic review and meta-analysis: early treatment responses of selective serotonin reuptake inhibitors in pediatric major depressive disorder. J Am Acad Child Adolesc Psychiatry 2015;54:557–64.

What is already known on this topic

Depressive disorders are frequent in children and adolescents.1 ,2 Several classes of antidepressants including selective serotonin reuptake inhibitors (SSRIs) are being used to treat paediatric depression.1 ,2 However, the management of depression in children and adolescents remains a difficult medical and social problem, especially taking into account that depression in adolescents is frequently associated with substance abuse, suicidal behaviour, inferior school functioning, problems in peer and family relationships.2

Methods of the study

The authors searched PubMed and CENTRAL for randomised controlled trials which compared SSRIs to placebo for the treatment of major …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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