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New use of antipsychotics associated with a small increased risk of acute kidney injury in older adults with mental disorders
  1. Julia Kirkham,
  2. Dallas Seitz
  1. Department of Psychiatry, Providence Care–Mental Health Services, Queen's University, 752 King Street West, Kingston, Ontario, Canada K7L 4X3
  1. Correspondence to Dr Dallas Seitz; seitzd{at}

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ABSTRACT FROM: Hwang YJ, Dixon SN, Reiss JP, et al. Atypical antipsychotic drugs and the risk for acute kidney injury and other adverse outcomes in older adults: a population-based cohort study. Ann Intern Med 2014;161:242–8.

What is already known on this topic

Antipsychotic use is increasing among older adults, who—as a result of age and frailty—may be particularly susceptible to adverse effects.1 Antipsychotics have already been associated with serious adverse events in older adults including falls, fractures and cardiovascular disease. Among older adults with dementia, they increase the risk of stroke and mortality.2 Other known effects of antipsychotics, such as hypotension, may increase the risk of developing acute kidney injury (AKI) in older adults. AKI is associated with clinically important negative outcomes and has not previously been described as an adverse effect of antipsychotic use in this population.3 Given the high prevalence of antipsychotic use among older adults with dementia and other mental disorders, AKI may be associated with significant morbidity and mortality.

Methods of the study

Hwang and colleagues undertook a large (n=97 777 matched …

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  • Competing interests DS has served on an advisory board for Eli-Lilly.