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Antidepressant exposure during the first trimester does not increase the risk of cardiac malformations in infants
  1. Jennifer L Payne
  1. Department of Psychiatry, Johns Hopkins School of Medicine, 550 N. Broadway, Suite 305, Baltimore, MD 21205, USA; Jpayne5{at}

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Previous studies have had conflicting and inconsistent findings regarding the rates of cardiac malformations in infants exposed to antidepressant medications during the first trimester. Concerns remain, particularly with regard to paroxetine, which has been associated with ventricular outflow tract obstruction,1 and sertraline, which has been associated with ventral septal defects.1 ,2 It has remained unclear if these associations are causal or if risk factors having to do with the underlying illness, depression, play a role. The goal of this study …

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  • Competing interests JLP has received legal consulting fees from law firms representing Astra Zeneca, Eli Lilly, Pfizer and Johnson & Johnson.

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