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What is already known on this topic?
Atomoxetine is a non-stimulant that has no abusive potential and a presynaptic inhibitor of the norepinephrine transporter, and has been found to be a safe and effective treatment for attention deficit/hyperactivity disorder (ADHD) in children, adolescents and adults.1
What this paper adds?
This is the largest meta-analysis of randomised controlled trials of atomoxetine for ADHD.
The effect size for atomoxetine versus placebo was higher for medication-naïve youth while factors such as demographic factors, mean dose, etc, did not moderate the treatment response.
Even though atomoxetine improved both inattentive and hyperactive symptoms, response was lower than for stimulants and 40% of participants taking atomoxetine had significant residual ADHD symptoms. Compared with placebo, a higher proportion of those taking atomoxetine had at least one adverse effect, experienced more weight loss and discontinued study participation.
Important treatment response moderators were not examined. For …
Competing interests None.
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