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What is already known on this topic?
Postictal psychosis is a well-recognised epileptic phenomenon, while there is also mounting evidence of increased prevalence of interictal psychosis and schizophrenia in people with epilepsy.1 The co-occurrence of these two disease states raises important questions about potentially shared pathological mechanisms and creates important challenges in their medical management.2
What does this paper add?
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First systematic review and meta-analysis examining the prevalence of psychosis in people with epilepsy.
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Pooled prevalence (a combination of lifetime, period and possibly point prevalence) of psychosis in those with epilepsy (including postictal psychosis, interictal psychosis and schizophrenia; 18 studies are included whose definition of psychosis is presumably unknown) alongside the odds of psychosis relative to those without epilepsy were reported.
Limitations
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The study authors comment on ‘substantial’ heterogeneity between included primary studies (I2>70%), and proceed with the meta-analysis using a random effects model to help accommodate this heterogeneity. Importantly, however, …
Footnotes
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Competing interests None.
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