You are here

Article Text

Article menu
Download PDFPDF
Causes and risk factors
The comorbidity of epilepsy and psychosis is an important area for continued research
  1. Gail S Bell,
  2. Mark R Keezer
  1. NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical & Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
  1. Correspondence to Gail S Bell, gail.bell{at}ucl.ac.uk

http://dx.doi.org/10.1136/eb-2014-101854

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    What is already known on this topic?

    Postictal psychosis is a well-recognised epileptic phenomenon, while there is also mounting evidence of increased prevalence of interictal psychosis and schizophrenia in people with epilepsy.1 The co-occurrence of these two disease states raises important questions about potentially shared pathological mechanisms and creates important challenges in their medical management.2

    What does this paper add?

    • First systematic review and meta-analysis examining the prevalence of psychosis in people with epilepsy.

    • Pooled prevalence (a combination of lifetime, period and possibly point prevalence) of psychosis in those with epilepsy (including postictal psychosis, interictal psychosis and schizophrenia; 18 studies are included whose definition of psychosis is presumably unknown) alongside the odds of psychosis relative to those without epilepsy were reported.

    Limitations

    • The study authors comment on ‘substantial’ heterogeneity between included primary studies (I2>70%), and proceed with the meta-analysis using a random effects model to help accommodate this heterogeneity. Importantly, however, …

    View Full Text

    Footnotes

    • Competing interests None.