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Children conceived following induced ovulation or intrauterine insemination have a small increased risk of mental disorders

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Question: Are children conceived after fertility treatment at increased risk of mental health disorders compared with spontaneously conceived children?

People: 33 139 children conceived after fertility treatment and 555 828 spontaneously conceived children (age 8 –17 years). This represented all children born in Denmark during the study years of interest (1995–2003) identified through the Danish Medical Birth Register (excluding children born to mothers aged less than 20 years).

Setting: Denmark; birth cohort, 1995–2003, follow-up in 2012

Risk factors: Fertility treatment, either with in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) or with hormone treatments to induce ovulation, with or without intrauterine insemination (IUI). IVF/ICSI exposure was identified through the Danish IVF Register, which collects information of each woman on cause of infertility, treatments given, pregnancy outcomes and identification of any children born. Exposure to hormone treatments (based on a drug list prespecified by the authors) was identified through the Danish National Prescription Register. Women were considered to have received hormone treatment for induced ovulation (OI) if they received a prescription up to 12 weeks before and 4 weeks after the date of their last menstrual period (women in …

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  • Sources of funding Aarhus University and The Augustinus Foundation, Denmark.


  • Competing interests None.

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