Article Text

Download PDFPDF
A dose reduction/discontinuation strategy improves long-term recovery in people with remitted first-episode psychosis compared to maintenance therapy

Statistics from


Question: What are the long-term effects of an antipsychotic dose-reduction/discontinuation (DR) strategy compared with maintenance treatment for people in remission from a first episode of psychosis?

Patients: One hundred and twenty-eight people with first-episode psychosis (FEP) who showed response of symptoms or sustained symptom remission during 6 months of antipsychotic treatment.

Setting: Seven mental healthcare organisations and the University Medical Center Groningen in the Netherlands.

Intervention: Antipsychotic dose DR, compared with maintenance therapy (MT) for 18 months. The DR strategy consisted of gradual symptom-guided tapering of dosage and discontinuation if feasible. MT was carried out according to the American Psychiatric Association guidelines, preferably using low-dose atypical antipsychotics.

Outcomes: Recovery at 7-year follow-up, defined as symptomatic and functional remission for at least 6 months. Symptom remission was assessed using the Positive and Negative Syndrome Scale (PANSS) and defined as a score below three on …

View Full Text


  • Sources of funding: Janssen-Cilag Netherlands and Friesland Mental Health Services, Leeuwarden, the Netherlands.


  • Competing interests None.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.