Article Text
PDF
Statistics from Altmetric.com
Question
Question: Are atypical antipsychotics effective and safe for treating disruptive behaviour disorders in children and young people?
Outcomes: Primary outcomes: aggression (measured using eg, aberrant behaviour checklist (ABC) Irritability Scale, overt aggression scale (OAS), overt aggression scale-modified (OAS-M)), conduct problems (measured using eg, Nisonger Child Behaviour Rating Form—Conduct Problem (NCBRF-CP), Conners’ Parent Rating Scale—Conduct Problem (CPRS-CP)), weight gain or change in body mass index (BMI) and metabolic parameters (adverse events).
Methods
Design: Systematic review and meta-analysis.
Data sources: CENTRAL, MEDLINE, EMBASE, PsycINFO, CINAHL, ClinicalTrials.gov, Australian New Zealand Clinical Trials Registry, CenterWatch and ICTRP were searched in August 2011.
Study selection and analysis: Double-blind randomised clinical trails (RCTs) including children and adolescents (≤18 years) with a diagnosis of a disruptive behaviour disorder (including oppositional defiant disorder, conduct disorder and unspecified disruptive behaviour disorder).Participants could have comorbid attention-deficit hyperactivity disorder (ADHD), major depression or an anxiety disorder, but trials were excluded if participants had a comorbid diagnosis of pervasive developmental disorder, autistic spectrum disorder, psychotic disorder or bipolar affective disorder.Meta-analyses were performed if studies were sufficiently similar. Random effects models were used. Continuous data were analysed …
Request Permissions
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.