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Review: antipsychotics do not increase weight in women with anorexia nervosa

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Question: How effective are antipsychotics in people with anorexia nervosa?

Outcomes: Body weight or body mass index (BMI) measured either by using the standardised mean difference (SMD) of the change in BMI from baseline to endpoint, the endpoint BMI or daily weight change. Secondary outcomes: anorexia nervosa symptoms (pooled Yale-Brown-Cornell Eating Disorder Scale, Eating Disorder Inventory, Anorectic Behaviour Scale, Body Shape Questionnaire and Eating Disorder Examination); depressive symptoms (pooled scores from Beck Depression Inventory, Personality Assessment Inventory Depression subscore and Center for Epidemiologic Studies Depression Scale) and anxiety (pooled scores from Beck Anxiety Inventory, Personality Assessment Inventory Questionnaire, Multidimensional Anxiety Scale for Children; side effects (akathisia, drowsiness/sedation).


Design: Systematic review with meta-analysis.

Data sources: Cochrane Library Databases, PsycINFO and PubMed were searched from inception until March 2012 for randomised controlled trials (RCTs). Reference lists of review articles and identified studies were hand searched.

Study selection and analysis: Two reviewers appraised the studies and selected RCTs comparing antipsychotics with placebo or usual care in people with anorexia nervosa. …

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  • Sources of funding: Dr Kishi is a postdoctoral fellow for research in the USA, additional support Japan Research Foundation for Clinical Pharmacology and the Ministry of Education.