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Review: little evidence that PUFA supplementation improves symptoms in ADHD

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Question: How effective are polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents?

Outcomes: Primary outcome: change in ADHD symptoms using validated scales. Secondary outcomes: behavioural problems, anxiety symptoms, depressive symptoms, quality of life, adverse effects, cost and loss to follow-up.


Design: Systematic review and meta-analysis.

Data sources: CENTRAL (The Cochrane Library 2011, Issue 2), MEDLINE (1948 to July Week 3, 2011), EMBASE (1980 to 2011 Week 29), PsycINFO (1806 to current), CINAHL (1937 to current), BIOSIS (1969 to 30 July 2011), Science Citation Index (1970 to 30 July 2011), Social Science Citation Index (1970 to 30 July 2011), Conference Proceedings Citation Index—Science (1990 to 30 July 2011), Conference Proceedings Citation Index—Social Science and Humanities (1990 to 30 July 2011), Cochrane Database of Systematic Reviews (2011, Issue 7), DARE (2011 Issue 2), Dissertation Abstracts (via Dissertation Express), the metaRegister of Controlled Trials (mRCT), the Digital Archive of Research Theses, the Networked Digital Library of Theses and Dissertations …

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  • Sources of funding: None.


  • Competing interests None.