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Review: non-steroidal anti-inflammatory drugs may reduce schizophrenia symptom severity in the short term when added to antipsychotics

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Question: Are non-steroidal anti-inflammatory drugs (NSAIDs) effective at reducing schizophrenia symptom severity when given in addition to antipsychotic medication?

Outcomes: Primary outcome: mean change in total score on the Positive and Negative Syndrome Scale (PANSS). Secondary outcomes: positive and negative symptom subscores of the PANSS or scores on the Scale for the Assessment of Positive Symptoms and Scale for the Assessment of Negative Symptoms.


Design: Systematic review and meta-analysis.

Data sources: MEDLINE, EMBASE, the National Institutes of Health website (, Cochrane Schizophrenia Group entries in PsiTri and the Cochrane Database of Systematic Reviews were searched (search date not reported) with no year or language restrictions. Reference lists of retrieved articles and additional relevant review articles were hand searched for additional studies.

Study selection and analysis: Double blind randomised controlled trials (RCTs) that augmented antipsychotic medication with an NSAID for patients with schizophrenia spectrum disorder (defined according to the Diagnostic and Statistical Manual of Mental Disorders criteria) were included. For inclusion studies …

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  • Sources of funding None reported.


  • Correspondence to Xiaoduo Fan, M.D., M.P.H., M.S., Biotech One, Suite 100, 365 Plantation Street, Worcester, MA 01605, USA;{at}

  • Competing interests None.