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Changes in occipital lobe gyrification may be an early marker for psychosis in youth with velo-cardio-facial syndrome

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Question: Is cortical gyrification a marker for psychosis in children and adolescents with velo-cardio-facial syndrome (VCFS)?

Population: 58 children aged 9–15 years with VCFS plus 21 unaffected siblings and 18 community controls in the same age range were assessed in the longitudinal part of the study. In addition, 91 children aged 6–9 years with VCFS, 29 unaffected siblings and 54 community controls were assessed cross-sectionally and their data pooled with the longitudinal sample's baseline assessment.

Setting: USA; time period not stated.

Prognostic factors: Cortical gyrification, quantified as the gyrification index (GI) using MRI.

Outcomes: Prodromal symptoms of psychosis (Scale of Prodromal Symptoms, SOPS). The SOPS categorises symptoms into: positive, negative, disorganised and general symptoms.


Design: Prospective cohort study.

Follow-up period: Three years (range 1.5–5.3 years).

Main results

At baseline, there was a significant difference in age between those with …

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  • Competing interests None.

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