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Review: adverse effects of different second-generation antipsychotics vary in children and adolescents

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Question: What are the most common short-term side effects of second-generation antipsychotics (SGAs) in children and adolescents?

Outcomes: Change in weight; clinically significant weight gain (considered >5% to >7% weight gain); change in glucose, cholesterol and triglycerides; change in prolactin; clinically significant hyperprolactinaemia; somnolence/sedation; clinical extrapyramidal symptoms (EPS) and/or akathisia.


Design: Systematic review and meta-analysis.

Data sources: MEDLINE and EMBASE were searched from 1996 to 2010. In addition the authors hand searched reference lists of relevant reviews, as well as Food and Drug Administration and European Medicines Agency databases for published and unpublished study data from 1980 to 2010.

Study selection and analysis: Prospective controlled clinical trials (randomised and non-randomised) of SGAs in children and adolescents that included a placebo or untreated group, lasted ≤12 weeks, and reported on adverse events were included. Exclusion criteria: studies with cross over, combination or discontinuation design; fewer than nine individuals per study arm; incomplete reporting of variables of interest. Study authors were contacted to obtain missing data. OR and …

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  • Competing interests None.

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