Statistics from Altmetric.com
Question: Is sertraline (SRT), cognitive behavioural therapy (CBT) or a combination of the two, effective at inducing remission among children and adolescents with anxiety disorders compared with placebo?
Patients: 488 children and adolescents aged between 7 and 17 years who met DSM-IV criteria for generalised anxiety disorder, social phobia and/or separation anxiety disorder.
Setting: Six sites, USA; from 2003 to 2008.
Intervention: SRT only, CBT only, SRT and CBT (COMB) or placebo pill treatment for 12 weeks.
Outcomes: Remission, defined in three different ways: (A) loss of all targeted anxiety disorders, assessed using the Anxiety Disorders Interview Schedule; (B) Clinical Global Impression Severity Scale (CGI-S) score of 1 (no symptoms) or 2 (minimal symptoms); (C) Clinical Global Impression Improvement Scale (CGI-I) score of 1 (very much improved).
Patient follow-up: 90% completed the study; 100% included in the analysis.
Design: Randomised controlled trial (the Child/Adolescent Anxiety Multimodal Study, CAMS).
Blinding: The SRT and PBO arms were double blinded while the CBT and COMB arms were single blinded (assessors only).
Follow-up period: 12 …
Sources of funding National Institute of Mental Health.
Competing interests None.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.