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Review: transition to psychosis is high in people with clinical high risk of developing psychosis

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Question: Is ‘clinical high risk (CHR)’ of developing psychosis associated with transition to psychosis?

Outcomes: Risk of transition to psychosis in high-risk patients, and transition risks at 6, 12, 18, 24, 36 and >36 months.


Design: Systematic review and meta-analysis.

Data sources: PubMed and EMBASE were searched up to January 2011. The authors hand searched reference lists of included articles. Search terms included: psychosis risk, ultra high risk, UHR, prodromal psychosis, psychosis transition, basic symptoms and psychosis onset. No language or date of publication restrictions were applied.

Study selection and analysis: Studies that reported transition risks in patients at high risk for psychosis were included. Inclusion criteria: original papers published in a peer-review journal; involved patients at high risk of psychosis defined by international criteria; reported transition risk to psychosis. Exclusion criteria: criteria for identifying high-risk patients not clearly defined inclusion of patients at genetic risk for schizotypal personality disorder or psychosis; overlapping study samples from the same centre. Demographic, clinical and methodological variables were included …

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  • Sources of funding The European Community's Seventh Framework Programme.


  • Competing interests None.