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Question
Question
How does clozapine compare with other atypical antipsychotics in the treatment of schizophrenia and schizophrenia-like psychoses?
Outcomes
Mental states assessed by a range of scales (Brief Psychiatric Rating Scale, Positive and Negative Syndrome Scale); adverse reactions; premature study exit; general/global functioning.
Methods
Design
Systematic review and meta-analysis.
Data sources
Cochrane Schizophrenia Groups Register (2007), reference lists, individual journals and conference proceedings, pharmaceutical company data.
Study selection and analysis
27 eligible studies were identified involving 3099 participants. Included studies were randomised, single or double blinded trials of clozapine versus other atypical antipsychotics. Eligible comparators were amisulpride, aripiprazole, olanzapine, quetiapine, risperidone, sertindole, ziprasidone and zotepine. Two authors independently selected studies and seven authors independently extracted data.
Main results
Eligible studies were found for five of the eight selected comparators (results summarised in online table). Overall attrition rates were high (30.1%), and data were lacking on outcomes …
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