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Review: cognitive impairment present in people with affective psychoses

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What are the characteristics and level of cognitive impairment in people with affective psychoses (APs)?


Effect size (Cohen's d) of difference in cognitive abilities measured over eight domains using a variety of reliable tests: general intelligence (current IQ, premorbid IQ); mental speed (symbol coding, Trail making A); memory (verbal learning, delayed recall); visual memory recall; executive function (Wisconsin Card Sorting Test (WCST)) categories, WCST perseverations, Trail making B, Stroop interference); verbal fluency (category fluency, letter fluency); sustained attention (continuous performance test (CPT)) and working memory (digit span backwards); effect of moderator variables on cognitive performance (gender, age, education, symptomatic status, age of onset and duration of illness).



Systematic review with meta-analysis.

Data sources

PubMed, PsycINFO, EMBASE and Scopus were searched from 1987 to May 2009 for comparative studies. Reference lists of identified studies were hand searched.

Study selection and analysis

Reviewers appraised studies and selected trials in adults comparing cognitive abilities in people with psychotic major depression (MDP) or psychotic bipolar disorder (BDP; ICD-9, ICD-10, DSM-III, DSM-III-R or DSM-IV criteria) with those in …

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  • Sources of funding National Health and Medical Research Council (NHMRC Program Grant (ID 56652); NHMRC Clinical Career Development Award, Melbourne Neuropsychiatry Centre.


  • Competing interests None.

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