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Do angiotensin receptor blockers protect against or slow the progression of dementia and Alzheimer's disease?
Participants were 819 491 older adults (98% male; aged ≥65 as of October 2002) with cardiovascular disease. More than 11 500 were taking angiotensin receptor blockers (ARBs), >91 000 were taking the angiotensin-converting enzyme (ACE) inhibitor lisinopril and >696 000 were taking other cardiovascular drugs (which included β blockers and calcium channel antagonists, and excluded ARBs, ACE inhibitors and statins). The study included those without a diagnosis of dementia or Alzheimer's disease at baseline (2001–2002) as well as those with these diagnoses.
Administrative database of the US Veteran Affairs; data collected October 2001 to September 2006.
Use of angiotensin receptor blockers, lisinopril, combinations of these or other cardiovascular medications. Lisinopril was selected as a comparator, as ACE inhibitors are a similar drug class to ARBs and share indications, and lisinopril has the largest group of users of the ACE inhibitors.
Time to incident of Alzheimer's disease or …
Sources of funding The Retirement Research Foundation and The Casten Foundation
Competing interests None.
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