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What is the impact of antipsychotic medications on brain volume and are there differences in the brain volumes of antipsychotic-naïve patients and healthy controls?
Overall brain volume, grey matter volume, lobar volumes, cerebrospinal fluid (CSF) volume and subcortical ventricular spaces, measured using MRI.
Medline searches for studies published between 1995 and April 2009.
Study selection and analysis:
To look at the effect of antipsychotic medication, longitudinal MRI studies were included that compared, at 6-month follow-up, brain-volume changes in patients with schizophrenia or psychosis and taking antipsychotics with that in healthy individuals. To look at whether there are baseline differences in brain-volume, studies looking at neuroleptic-naive patients or patients with minimal treatment (≤4 weeks) compared with healthy controls were included. Research works that focused on people from ‘high-risk’ samples, who were considered to be at high risk of psychosis due to genetic loading or subclinical symptoms, were also included.
A total of 26 longitudinal studies were identified that satisfied inclusion criteria. The studies involved a total of 767 patients experiencing …
Sources of funding No financial support was received for this study.
Competing interests None.