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What is the efficacy and safety of variable dose olanzapine in people with borderline personality disorder?
314 outpatients (aged 18–65 years) with borderline personality disorder (DSM-IV) and scoring 9 on the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) score at randomisation (see online notes for main exclusion criteria).
52 sites in nine countries: Belgium, France, Germany, Norway, Portugal, Spain, Sweden, UK and USA; time period not stated.
Olanzapine (2.5–20 mg/day) or placebo. Participants taking olanzapine started on 2.5 mg or 5 mg/day based on the investigator’s judgement. After 1 week, if needed, doses could be increased or decreased in 2.5 or 5 mg doses to a maximum of 20 mg/day. At week 4, participants without a ⩾30% reduction in the ZAN-BPD score were prescribed incremental dose increases (up to a maximum of 20 mg/day) unless precluded by adverse events. Participants on maximum dose and failing to achieve a reduction in score remained in the study at the investigator’s discretion.
The primary outcome measure was mean change from …
Source of funding: Eli Lilly.
Competing interests: None.
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