Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Does high dose vitamin B supplementation have an effect on cognitive decline in people with Alzheimer’s disease?
409 people with mild to moderate probable Alzheimer’s disease (NINCDS-ADRDA criteria; mean age 76 years; 56% female; 41% multivitamin users; 91% using cholinesterase inhibitors). Exclusions: <50 years old; medically unstable, Mini-Mental State Examination score <14 or >26; vitamin B12 or folate insufficiency (vitamin B12 <175 pg/ml; folate <4.2 ng/ml); renal insufficiency (serum creatine ⩾2.0 mg/dl); daily vitamin supplementation with >400 μg folic acid; used sedatives, anti-Parkinson’s or drugs with anticholinergic effects in the past 2 months; or recent investigational treatment for Alzheimer’s disease. Stable use of cholinesterase inhibitors or memantine was allowed if it had been ongoing for at least 3 months.
40 sites across the USA; recruitment: February 2003 to December 2006.
High dose vitamin B supplementation (5 mg folic acid, 1 mg vitamin B12 (cyanocobalamin) and 25 mg vitamin B6 (pyridoxine hydrochloride) per day) or placebo for 18 months.
Change in cognitive …
Source of funding: National Institute on Aging, USA.