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Review: non-pharmacological interventions reduce antipsychotic induced weight gain

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Are non-pharmacological interventions effective in controlling antipsychotic induced weight gain in people with schizophrenia spectrum disorders?


Primary: change in body weight; change in body mass index (BMI) post-treatment; secondary: body weight and BMI at follow-up.



Systematic review with meta-analysis.

Data sources:

The following databases were searched in May 2007: Cochrane Central Register of Controlled Trials, Medline, EMBASE, PsycINFO, CINAHL, UMI Proquest Digital Dissertations, Information Science Citation Index Expanded Information Social Sciences Citation Index, Information Arts and Humanities Citation Index, registers of ongoing clinical trials, ISI Science and Technology proceedings and ISI Information Social Science and Humanities proceedings. Hand searching of reference lists and key journals (from January 2000 to May 2007) was used to identify additional articles.

Study selection and analysis:

The review included randomised controlled trials (RCTs) comparing the efficacy of non-pharmacological interventions to care as usual or an active comparator in preventing or reducing weight gain associated with antipsychotic use (typical or atypical) in patients with schizophrenia (chronic or recent onset, inpatient or outpatient). Exclusions: less than 75% of participants meeting diagnostic …

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  • Source of funding: Marques de Valdecilla Public Foundation–Marques de Valdecilla Research Institute, Santander, Spain.


  • Competing interests: RM is on the advisory boards of, and has been an invited speaker for, a number of pharmaceutical companies.