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How do different psychotropic medications affect the risk of fractures in elderly people?
63 081 people aged 50 years and older identified through the Canadian Manitoba Health database. Cases (n = 15 792) were people with vertebral, wrist or hip osteoporotic fractures (ICD-9-CM). Controls (n = 47 289; up to three for each case) were those without osteoporotic fractures. Exclusions: did not have continuous health cover during the study period, resident in long term care facility, osteoporosis drug use in the year prior to fracture.
Manitoba, Canada; April 1996–March 2004.
Use of psychotropic medications. These included selective serotonin reuptake inhibitors (SSRIs), other monoamine antidepressants, benzodiazapines, typical antipsychotics, atypical antipsychotics and lithium. Use of psychotropic medications was defined as current use (<120 days before index date), past use (within 121–365 days before the index date) and non-use (>365 days before the index date). The Manitoba drug dispensing database was used as a proxy measure of psychotropic medication …
Source of funding: Canadian Institutes for Health Research and the Canadian Institutes for Health New Investigators Award.
Competing interests: None.
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