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Varying effects of psychotropic medications on fracture risk in older people

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How do different psychotropic medications affect the risk of fractures in elderly people?


63 081 people aged 50 years and older identified through the Canadian Manitoba Health database. Cases (n = 15 792) were people with vertebral, wrist or hip osteoporotic fractures (ICD-9-CM). Controls (n = 47 289; up to three for each case) were those without osteoporotic fractures. Exclusions: did not have continuous health cover during the study period, resident in long term care facility, osteoporosis drug use in the year prior to fracture.


Manitoba, Canada; April 1996–March 2004.

Risk factors:

Use of psychotropic medications. These included selective serotonin reuptake inhibitors (SSRIs), other monoamine antidepressants, benzodiazapines, typical antipsychotics, atypical antipsychotics and lithium. Use of psychotropic medications was defined as current use (<120 days before index date), past use (within 121–365 days before the index date) and non-use (>365 days before the index date). The Manitoba drug dispensing database was used as a proxy measure of psychotropic medication …

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  • Source of funding: Canadian Institutes for Health Research and the Canadian Institutes for Health New Investigators Award.


  • Competing interests: None.

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