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Osmotically released methylphenidate is more effective than atomoxetine in children and adolescents with ADHD

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Is osmotically released methylphenidate more effective than atomoxetine or placebo in children and adolescents with attention deficit hyperactivity disorder (ADHD)?


516 children and adolescents with DSM-IV ADHD (aged 6–16 years; 26% female, mean age 10.2 years). Exclusions: ADHD symptom severity <1.5 standard deviations above average on the ADHD Rating Scale IV-parent version; seizures, bipolar disorder, psychotic illness, anxiety and tic disorders, or pervasive developmental disorder; use of psychoactive medications; or experienced intolerable adverse events or no improvement when previously treated with study drugs.


20 sites, USA; time period not stated.


Osmotically released methylphenidate (n = 220; single morning dose of 18–54 mg/day), atomoxetine (n = 222; twice daily divided dose of 0.8–1.8 mg/kg/day) or placebo (n = 74) for 6 weeks. Washout of any psychoactive medication for at least 5 days was required prior to entry.


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  • Source of funding: Eli Lilly and Company, USA.


  • Competing interests: None.

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