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Review: Adding psychosocial interventions to pharmacotherapy for opioid detoxification improves outcomes

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How effective is adding psychosocial to pharmacological treatment for opioid detoxification?


Completion of treatment (the detoxification programme), use of opioid drugs (assessed by urinalysis during treatment) and abstinence from opioids at follow-up.



Systematic review with meta-analysis.

Data sources:

The following databases were searched in February 2008: Cochrane Drugs and Alcohol Group trials register, Cochrane Central Register of Controlled Trials, PubMed (from 1996), EMBASE (from January 1980), CINAHL (from January 2003) and PsycINFO (from 1985 to April 2003). Conference proceedings and databases of ongoing trials were also searched and investigators contacted to obtain details of unpublished or ongoing trials. Reference lists of relevant articles were searched to identify additional citations.

Study selection and analysis:

Randomised controlled trials (RCTs) which compared psychosocial plus pharmacological treatment versus pharmacological treatment alone for opioid detoxification in adults (aged 18 years and over). RCTs in pregnant …

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  • Source of funding: Department of Epidemiology, ASL RM/E, Italy; Evidence for Drugs and Alcohol Policy Project (sponsored by the European Community-Directorate Public Health).


  • Competing interests: None.