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Do antipsychotic medications differ in the ability to reduce violent behaviour in people with schizophrenia?
1493 adults with schizophrenia (DSM-IV), aged 18–65 years. Detailed inclusion and exclusion criteria are not reported in this article.
The NIMH Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project; 57 US sites (academic and community); January 2001–December 2004.
Olanzapine (7.5 mg capsule), quetiapine (200 mg capsule), risperidone (1.5 mg), perphenazine (8 mg capsule) or ziprasidone (40 mg capsule). Doses were altered according to clinical judgement, with up to 4 capsules given daily.
Primary outcome: change in violent behaviour from baseline to 6 months (MacArthur Community Violence Interview—a combined measure of minor (eg, assault without injury) and serious (eg, assault with a weapon) violent behaviours). Information was collected from both the participant and family members.
45% of participants completed 6 months of treatment and were included in the retained sample; 97% were included in the intention to treat (ITT) sample (48 participants were excluded …
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