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Review: Insufficient evidence to guide use of drugs for clozapine induced hypersalivation

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Is drug therapy effective for reducing clozapine induced hypersalivation?


Measurement of salivation, measured as cure, no change, endpoint salivation score or change in salivation scores. Secondary outcomes included assessment of global state, service use, mental state, general functioning, behaviour, adverse effects, engagement, quality of life, satisfaction and costs.



Systematic review with meta-analysis.

Data sources:

Cochrane Schizophrenia Group Trials Register; search to March 2007.

Study selection and analysis:

Six reviewers independently selected and appraised RCTs comparing treatment with any pharmacological intervention versus placebo or no treatment for any condition in populations, regardless of age and gender, all of whom had identified clozapine induced hypersalivation (identified by self, carer or clinician). Disagreements were resolved by consensus (see online notes for further methodological details). Reviewers performed several meta-analyses, pooling dichotomous results and continuous data for each outcome and comparator. Only some of these results are presented here.

Main results

Fifteen …

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  • Competing interests: GR has received research funding from Novartis and Merck Germany.

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