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Little difference between haloperidol, risperidone and olanzapine in weight gain after 1 year of treatment

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What effects do haloperidol, risperidone and olanzapine have on weight gain in drug-naive psychotic patients after 1 year?


164 drug-naive first episode psychotic patients (15 to 60 years old; mean age 27 years, mean body mass index (BMI) 23.1 kg/m2) with DSM IV brief psychotic disorder, schizophreniform disorder, schizophrenia or schizoaffective disorder who were consecutively referred to several psychiatric units in Spain. Exclusion criteria: drug dependence, mental retardation, serious medical comorbidity.


Outpatient and inpatient psychiatric units of one university hospital, Cantabria, Spain; February 2001 to February 2005.


Haloperidol (3–9 mg/day), olanzapine (5–20 mg/day) or risperidone (3–6 mg/day) for 12 months. Patients were switched to a different antipsychotic if they did not respond to 6 weeks of treatment or if they had significant side effects.


Change in body weight and BMI. Measurements taken at 12 weeks and 1 year follow-up. Analyses were adjusted for baseline BMI, age and sex.

Patient follow-up:

90% completed 3 months’ …

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  • Source of funding: Intituto de Salud Carlos III and SENY Fundatio Research Grant (Fundacion Marques de Valdecilla).

  • Additional notes are published online only at


  • Competing interests: None.