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What effects do haloperidol, risperidone and olanzapine have on weight gain in drug-naive psychotic patients after 1 year?
164 drug-naive first episode psychotic patients (15 to 60 years old; mean age 27 years, mean body mass index (BMI) 23.1 kg/m2) with DSM IV brief psychotic disorder, schizophreniform disorder, schizophrenia or schizoaffective disorder who were consecutively referred to several psychiatric units in Spain. Exclusion criteria: drug dependence, mental retardation, serious medical comorbidity.
Outpatient and inpatient psychiatric units of one university hospital, Cantabria, Spain; February 2001 to February 2005.
Haloperidol (3–9 mg/day), olanzapine (5–20 mg/day) or risperidone (3–6 mg/day) for 12 months. Patients were switched to a different antipsychotic if they did not respond to 6 weeks of treatment or if they had significant side effects.
Change in body weight and BMI. Measurements taken at 12 weeks and 1 year follow-up. Analyses were adjusted for baseline BMI, age and sex.
90% completed 3 months’ …
Source of funding: Intituto de Salud Carlos III and SENY Fundatio Research Grant (Fundacion Marques de Valdecilla).
Additional notes are published online only at http://ebmh.bmj.com/content/vol11/issue4
Competing interests: None.
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