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Schizophrenia associated with increased risk of colon cancer but reduced risk of respiratory cancer

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Dr Julia Hippisley-Cox

Correspondence to: Dr Julia Hippisley-Cox, Division of Primary Care, University of Nottingham, 13th Floor Tower Building, University Park, Nottingham NG7 2RD, UK;



Are people with schizophrenia or bipolar disorder at increased risk of developing any of six common cancers?


40 441 adults (cases; aged 25–100 years) with first record of breast, colon, rectal, respiratory, prostate or gastroesophageal cancer during the study period (including postmortem diagnoses), plus 193 290 controls (up to 5 per case selected by incidence density sampling) matched by age, sex and general practice, and alive at the time of cancer diagnosis in their matching case (index date). Cases and controls were selected from just over 4 million people registered with general practices recorded on the QRESEARCH electronic database during the study period. This database contains anonymised UK primary care records for a representative sample of 6% of all general practices in the UK. Exclusions: any cancer diagnosis before the study period; patients with <12 months computerised medical data prior to index date (cancer diagnosis); cases of breast cancer with mastectomy or tamoxifen …

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  • Source of funding: UK Disability Rights Commission, University of Nottingham and National Health Service.

  • ▸ Additional notes and references are published online only at


  • Competing interests: None.

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