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  • Tranquilising agitated mentally ill patients: intramuscular haloperidol plus promethazine reduces need for additional medication or medical attention compared to olanzapine

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Therapeutics
Tranquilising agitated mentally ill patients: intramuscular haloperidol plus promethazine reduces need for additional medication or medical attention compared to olanzapine
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http://dx.doi.org/10.1136/ebmh.11.3.87

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    P Tharyan

    Correspondence to: P Tharyan, Department of Psychiatry, Christian Medical College, Vellore and BV Moses Centre for Clinical Trials and Evidence Based Medicine, Christian Medical College, Vellore 632002, Tamil Nadu, India; prathap@cmcvellore.ac.in

    QUESTION

    Question:

    Intramuscular haloperidol plus promethazine or intramuscular olanzapine: which is more effective for the emergency treatment of agitated and violent adults with mental illness?

    Patients:

    300 hospitalised adults with mental illness (ICD-10 classified), presenting with aggressive or violent behaviour. Inclusions: consecutive patients in the psychiatric unit for whom intramuscular sedation was indicated and where intervention did not put the patient at risk.

    Setting:

    Psychiatric unit of the Christian Medical College, Vellore, South India; September 2005 to July 2006.

    Intervention:

    Single intramuscular injection …

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    2008 BMJ Publishing Group Ltd, the British Psychological Society and the Royal College of Psychiatrists