Statistics from Altmetric.com
Correspondence to: Professor Howard, Medical Research Council Centre for Neurodegeneration Research, Institute of Psychiatry, King’s College London, DeCrespigny Park, London SE5 8AF, UK; Robert.firstname.lastname@example.org
Is donepezil effective for behavioural disturbance in people with Alzheimer’s disease that have not responded to psychosocial treatment?
250 adults (>39 years old; 85% female; 93% in residential care) with Alzheimer’s disease (possible or probable according to Neurological and Communication Disorders and Stroke-Alzheimer’s disease and Related Disorders Association criteria) and distressing agitation causing management problems for caregivers on ⩾2 days per week for 2 weeks and that had not responded to up to 4 weeks of psychosocial treatment prior to randomisation. Other inclusion criteria: Cohen-Mansfield Agitation Inventory (CMAI) score ⩾39; living in residential care or with a permanent carer; were consenting to treatment or were assenting and with a caregiver in agreement with participation. Exclusions: treatment with neuroleptics or cholinesterase inhibitors within past 4 weeks, or planned for such treatment in next …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.