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Prognostic factors for progression to psychosis in high risk youth

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Tyrone D Cannon

Correspondence to: Tyrone D Cannon, PhD, Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095, USA;



How common is conversion to psychosis in high risk youths, what factors predict this risk?


370 people (mean age 18 years) with prodromal psychotic symptoms (according to Structured Interview for Prodromal Syndromes (SIPS) criteria) who had been referred by school counsellors or community-based mental health professionals. The main SIPS criteria include: onset or worsening in the preceding 12 months of attenuated positive thoughts in one or more of five categories (grandiosity, unusual thought, paranoia/suspicion, disorganised communication, or perceptual abnormalities; rated from 0 (none) to 6 (fully psychotic state), score of 3–5 indicates a prodromal state); onset in previous 3 months of brief intermittent psychotic symptoms not meeting DSM-IV threshold for psychotic disorder; or the combination of deterioration of ⩾30% on the General Assessment of Functioning Scale in the past 12 months plus a genetic risk factor (either schizotypal personality disorder or a first degree relative with psychotic disorder).


Eight clinical research centres …

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  • Competing interests: AY received an Investigator Initiated grant from the Janssen Research Foundation for a treatment trial in the UHR group.

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