Article Text

Download PDFPDF
More severe symptoms of depression increase coronary heart disease mortality

Statistics from Altmetric.com

Dr M Ahto

Correspondence to: Dr M Ahto, Hakatie Health Centre, Hyvattylantie 7, FI-21420 Lieto, Finland; merahto@utu.fi

QUESTION

Question:

Does depression increase the risk of death from coronary heart disease?

People:

660 people (57% women) without coronary heart disease (CHD) who were born in 1926 or earlier, and identified through a study of chronic disease epidemiology in the elderly carried out in southwestern Finland from 1990–1991. Presence of CHD was identified through patient history, medical records and ECG. Baseline exclusions: previous myocardial infarction, angina, ischemic change on the ECG, or past coronary artery bypass graft or angioplasty.

Setting:

Rural Finland; 1990–2002.

Risk factors:

Severity of depression (assessed with Zung Self-rating Depression Scale (ZSDS); range 20–80 points; more severe symptoms of depression classified as ⩾45 points). Multivariable hazards ratios were calculated using Cox proportional hazard regression, accounting for potential predictors …

View Full Text

Footnotes

  • Notes: Although the paper suggests that 661 people were included in the study, only 660 are detailed as participants. When compared to DSM-III criteria for diagnosing depression in those aged ⩾65, ZSDS score cut off of 44/45 had 72% sensitivity and 83% specificity. There may be inaccuracies in classification of cause of death. Lipid levels, which could have a confounding affect upon mortality in depressed people, were not examined.

  • Source of funding: The Signe and Arne Gyllenberg Foundation, The Academy of Finland.

Footnotes

  • Competing interests: None.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.