- First published April 25, 2008.
web only references 11/2/49
Subgroup analyses of specific types of psychotherapy models showed significant post-treatment benefit of PT over control for BT (RR response: 6.76, 95% CI 1.45 to 31.40; p=0.01), IPT (RR response: 1.68, 95% CI 1.08 to 2.63; p=0.02), and CBT (RR response: 1.38, 95% CI 1.14 to 1.66; p=0.0009). At 1�6 month follow-up and 6�12 month follow-ups, there were no differences in response between different models of PT and control conditions. Subgroup analyses by control condition revealed significant post-treatment benefit of PT over attention-placebo (RR response: 1.48, 95% CI 1.12 to 1.96; p=0.006). This benefit was not evident at 1�6 month or 6�12 month follow-ups. There was a significant post-treatment benefit of PT over waiting list control (RR response: 2.00, 95% CI 1.34 to 2.98; p=0.0006), and also at 1�6 months (RR response: 1.98, 95% CI 1.27 to 3.07). There was no difference in response between PT (combined with TAU) and TAU alone, or PT and no treatment at any time point. PT improved post-treatment response in adolescents (RR response: 1.35, 95% CI 1.10 to 1.66; p=0.004), but not among children (6�12 years). PT improved response regardless of depression severity (mild to moderate or moderate to severe).
However, the analyses did not correct for the multiple subgroup analyses. This may have led to false-positive conclusions.
Most of the trials examined adolescents aged 12�18 years (81%), and were in people with mild to moderate depression (79%); 64% of participants were female. Follow-up ranged from between 1�6 months (14 studies) and 6�12 months (8 studies). Trials varied in methodological quality and diagnostic criteria used for diagnosing depression. Heterogeneity between studies was significant (p=0.04) and publication bias was significant (p <_0.001. _--="_--" end="end" desc="desc" dc1="dc1">
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