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Citalopram-resistant depression: cognitive therapy and medication similarly effective as second line treatments

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Citalopram-resistant depression: cognitive therapy and medication similarly effective as second line treatments

Publication history

  • First published April 25, 2008.
Online issue publication 
April 25, 2008
  • web only notes 11/2/48

    As a result of the small number of participants in arms that allowed comparison of cognitive therapy with pharmacotherapy, the study has reduced power. Authors� post hoc power calculation suggests the study had power to detect only large differences between treatments in remission rates (over 20% difference). For the primary outcome, authors used a conservative intention to treat analysis (assumed that people with missing HAM-D scores did not achieve remission). The study did not provide a comparison between augmentation and switch strategies. The design of the STAR*D study may have led to bias in the participating sample, as the proportion of people who accepted psychotherapy was lower than expected.

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